Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle

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Publisher: National Academy of Sciences
Document Type: Article
Length: 91 words

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Abstract :

Leukocyte adhesion deficiency (LAD) is an autosomal recessive disorder characterized by multiple defects in leukocyte function resulting from the reduced expression of beta-2 integrin. The genetic determinant of LAD in Holstein cattle was determined by analyzing the sequence of leukocyte RNA in normal and diseased cows. The result showed that cows suffering from LAD contain a point mutation in the gene coding for the CD18 subunit of beta-integrin. Pedigree analysis showed that all the diseased cattle tested are related to one bull, which sired many calves in the 1950s and 1960s.

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Gale Document Number: GALE|A14264876