Diurnal pattern in skin [Na.sup.+] and water content is associated with salt-sensitive hypertension in [ET.sub.B] receptor-deficient rats

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Publisher: American Physiological Society
Document Type: Author abstract
Length: 251 words

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Abstract :

Impairment in the ability of the skin to properly store [Na.sup.+] nonosmotically (without water) has recently been hypothesized as contributing to salt-sensitive hypertension. Our laboratory has shown that endothelial production of endothelin-1 (ET-1) is crucial to skin [Na.sup.+] handling. Furthermore, it is well established that loss of endothelin type B receptor ([ET.sub.B]) receptor function impairs [Na.sup.+] excretion by the kidney. Thus we hypothesized that rats lacking functional [ET.sub.B] receptors ([ET.sub.B]-def) will have a reduced capacity of the skin to store [Na.sup.+] during chronic high-salt (HS) intake. We observed that [ET.sub.B]-def rats exhibited salt-sensitive hypertension with an approximate doubling in the diurnal amplitude of mean arterial pressure compared with genetic control rats on a HS diet. Two weeks of HS diet significantly increased skin [Na.sup.+] content relative to water; however, there was no significant difference between control and [ET.sub.B]-def rats. Interestingly, HS intake led to a 19% increase in skin [Na.sup.+] and 16% increase in water content (relative to dry wt.) during the active phase (zeitgeber time 16) versus inactive phase (zeitgeber time 4, P circadian rhythm; endothelin; salt; skin; sodium doi: 10.1152/ajpregu.00312.2017

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Gale Document Number: GALE|A539646924