Low and High Ambient Temperatures during Pregnancy and Birth Weight among 624,940 Singleton Term Births in Israel (2010-2014): An Investigation of Potential Windows of Susceptibility.

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From: Environmental Health Perspectives(Vol. 129, Issue 10)
Publisher: National Institute of Environmental Health Sciences
Document Type: Report
Length: 10,786 words
Lexile Measure: 1550L

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Abstract :

Background: Exposure to heat during pregnancy has been associated with reduced fetal growth. Less is known about associations with cold and the potential for critical time windows of exposure. OBJECTIVES: We aimed to evaluate, in a national retrospective cohort, critical windows of susceptibility during pregnancy to extreme temperatures (low and high) and fetal growth, among 624,940 singleton term births in Israel during the period 2010-2014. Methods: Temperature exposures were estimated using a spatially refined gridded climate data set with a 1-h and 1- [km.sup.2] resolution. Percentiles of temperature were categorized by climatic zone for the entire pregnancy and by trimesters and weeks. Generalized additive models with the distributed lag nonlinear model framework were used to estimate unadjusted and adjusted associations between percentiles and categories of temperature and fetal growth markers: term [births after 36 weeks of gestational age (GA)] mean birth weight and term low birth weight (tLBW, term infants with birth weight below 2,500 g). Results: After adjustment, extreme temperatures (percentiles) during the entire pregnancy were associated with a lower mean birth weight { 90th vs. 41st-50th percentile: -65 g; 95% CI: -72 g, -58 g}. Similar inverse U-shaped patterns were observed for all trimesters, with stronger associations for heat than for cold and for exposures during the third trimester. For heat, results suggest critical windows between 3-9 and 19-34 GA-weeks, with the strongest association estimated at 3 GA-weeks (temperature 90th vs. 41st-50th percentiles: -3.8 g; 95% CI: -7.1 g, -0.4 g). For cold, there was a consistent trend of null associations early in pregnancy and stronger inverse associations over time, with the strongest association at 36 GA-week ( Discussion: Findings from our study of term live births in Israel (2010-2014) suggest that exposure to extreme temperatures, especially heat, during specific time windows may result in reduced fetal growth. https://doi.org/10.1289/EHP8117

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Gale Document Number: GALE|A679525399