Comparison between Xingnaojing Injection (e'e"'e[TM]ae[superscript three]¨a[degrees]"ae¶[superscript two]) and Naloxone in Treatment of Acute Alcohol Intoxication: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.

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From: Chinese Journal of Integrative Medicine(Vol. 25, Issue 12)
Publisher: Springer
Document Type: Report
Length: 500 words

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Keywords: Xingnaojing Injection; naloxone; acute alcohol intoxication; meta-analysis; randomized controlled trial Abstract: Objectives To investigate the effectiveness and safety of Xingnaojing Injection (XNJ, éèéæ³¨å° æ¶²) compared with naloxone for the treatment of acute alcohol intoxication (AAI), and provide the latest evidence through evidence-based approach. Methods Seven electro-databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure Databases, Chinese Biomedical Literature Database, Chinese Science and Technology Periodical Database (VIP) and Wanfang Database were searched from the inception to January 2018. Randomized controlled trials (RCTs) comparing XNJ with naloxone for patients with AAI and reporting at least one of the below outcomes were included: patients' conscious recovery time, stay length in emergency department, disappearance time of the ataxia symptom, the severity of the symptoms, the blood alcohol content as well as the adverse events. Methodological quality of included trials was assessed using the risk of bias tool which recommended by the Cochrane Collaboration. Meta-analysis was conducted by Review Manager 5.3 software. Results Totally 141 trials with 13,901 patients were included in this review, all of them were assessed as unclear or high risk of bias. Results showed that on the basis of routine therapy, standard dose XNJ (10--20 mL) may have similar results with naloxone on the recovery time of consciousness (MD 12 min, 95% CI 7.2--17.4 min) and disappearance time of symptoms (MD 6 min, 95% CI--13.8--25.8 min) for patients with AAI. Larger dose of XNJ Injection (21--40 mL) may speed up the time (almost 1 h earlier). Combination of XNJ and naloxone seemed superior to the naloxone alone for all the relevant outcomes. The average difference of time in consciousness recovery was 2 h and the number of AAI patients whose consciousness recovery within 1 h was above 50% the combination group than in the control group (RR 1.42, 95% CI 1.29 to 1.56). No severe adverse events or adverse reactions of XNJ were reported in the included trials. Conclusions Low quality of evidence showed XNJ may have equal effect as naloxone and may achieve better effect as add-on intervention with naloxone for patients with AAI. We failed to evaluate the safety of XNJ Injection due to the insufficient evidence in this review. Registration number. in PROSPERO (No. CRD42018087804) Author Affiliation: (1) grid.24695.3c, 0000 0001 1431 9176, Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China (2) grid.24695.3c, 0000 0001 1431 9176, First Clinical Medical College of Beijing University of Chinese Medicine, Beijing, 100029, China (3) grid.24695.3c, 0000 0001 1431 9176, School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 100029, China Article History: Registration Date: 05/08/2019 Accepted Date: 23/05/2018 Online Date: 05/08/2019 Article note: Supported by the National Natural Science Foundation of China (No. 81473547, 81673829) and the Beijing Municipal Organization Department Talents Project (No. 2017000020124G292) Electronic Supplementary Material Supplementary material is available for this article at https://doi.org/10.1007/s11655-019-3037-3 and is accessible for authorized users. Byline: Hui-juan Cao (1), Nuo Cheng (2), Rui-ting Wang (2), Xing-yue Huang (3), Jia-rui Wu (3)

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Gale Document Number: GALE|A607587016