Soft Tissue Special Issue: Myoepithelial Neoplasms of Soft Tissue: An Updated Review with Emphasis on Diagnostic Considerations in the Head and Neck.

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Author: Vickie Y. Jo
Date: Mar. 2020
From: Head and Neck Pathology(Vol. 14, Issue 1)
Publisher: Springer
Document Type: Report; Brief article
Length: 164 words

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Abstract :

Keywords: Head and neck; Soft tissue; Myoepithelioma; Myoepithelial carcinoma; Mixed tumor; EWSR1; PLAG1 Abstract Primary myoepithelial neoplasms of soft tissue have been shown to be related to their salivary gland counterparts, with which they often share morphologic, immunophenotypic, and molecular genetic features, such as the presence of PLAG1 rearrangement in both soft tissue mixed tumor and salivary pleomorphic adenoma. However, important distinctions remain between soft tissue and salivary myoepithelial neoplasms, namely differing criteria for malignancy. This review provides an overview of the current understanding of the clinicopathologic and molecular features of soft tissue myoepithelial neoplasms, including discussion of the similarities and differences between soft tissue and salivary counterparts and relevant diagnostic issues specific to head and neck pathology practice. Author Affiliation: (1) Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, 02115, Boston, MA, USA (a) Article History: Registration Date: 11/29/2019 Received Date: 11/06/2019 Accepted Date: 11/29/2019 Online Date: 01/16/2020 Byline: Vickie Y. Jo (corresponding author) (1, a)

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Gale Document Number: GALE|A658325207