The role of [alpha]-synuclein and LRRK2 in tau phosphorylation

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Date: Annual 2015
Publisher: Hindawi Limited
Document Type: Report
Length: 7,619 words
Lexile Measure: 1610L

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Abstract :

There is now a considerable body of experimental evidence that Parkinson's disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role of [alpha]-synuclein and LRRK2 in the abnormal phosphorylation of tau. In addition, as recent reports have indicated that heat shock proteins- (HSPs-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology, we also discuss therapeutic strategies for PD focusing on inhibition of [alpha]-synuclein- and LRRK2-associated tau phosphorylation by HSPs.

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Source Citation   

Gale Document Number: GALE|A462046577