NR4A3 Immunohistochemistry Reliably Discriminates Acinic Cell Carcinoma from Mimics.

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From: Head and Neck Pathology(Vol. 15, Issue 2)
Publisher: Springer
Document Type: Report; Brief article
Length: 358 words

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Keywords: Salivary gland; Acinic cell carcinoma; Secretory carcinoma; NR4A3; IHC; FISH Abstract Acinic cell carcinoma (AciCC) harbors a recurrent t(4 9)(q13 q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). Previous work on tissue microarrays suggests that NR4A3 immunohistochemistry (IHC) may be useful in the diagnosis of AciCC. Thus far, only a single study has evaluated the utility of NR4A3 immunohistochemistry (IHC) in the diagnosis of AciCC, using a tissue microarray to assess most non-AciCC tumor types. Herein we evaluate the diagnostic performance of NR4A3 IHC for AciCC in a large cohort of 157 salivary gland tumors, using whole tissue sections. The cohort consisted of 37 AciCC (6 of them (16%) with high grade transformation), 30 secretory carcinomas (SC), and 90 additional salivary gland tumors, including mucoepidermoid carcinomas (MEC), polymorphous adenocarcinomas (PAC), pleomorphic adenomas (PA), salivary duct carcinomas (SDC), and adenoid cystic carcinomas (AdCC). NR4A3 nuclear staining by IHC was considered positive if present in more than 5% of tumor cells. Overall, 92% of AciCC (34/37) expressed NR4A3 by IHC, with strong (89%) or moderate (3%) nuclear staining, yielding a sensitivity of 92%. IHC detected NR4A3 expression in all cases of recurrent/metastatic AciCC and tumors with high grade transformation. Importantly, all SC were negative for NR4A3 IHC, with no staining in 28/30 cases and weak focal staining, in Author Affiliation: (1) Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, 02115, Boston, MA, USA (d) Article History: Registration Date: 08/17/2020 Received Date: 07/13/2020 Accepted Date: 08/17/2020 Online Date: 09/10/2020 Byline:

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Gale Document Number: GALE|A662360301