Steric control of [alpha]- and [beta]-alkylation of azulenone intermediates in a guanacastepene A synthesis

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From: Journal of Organic Chemistry(Vol. 75, Issue 3)
Publisher: American Chemical Society
Document Type: Report
Length: 46 words

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Abstract :

The origins of different stereoselectivities observed in the alkylations of azulenone precursors in the guanacastepene A synthesis are determined through density functional theory examinations. The optimized transition structures of methylation of two different guanacastepene A precursors have shown that steric effects have dictated the preferred products.

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Gale Document Number: GALE|A219643329