Synthesis of cis-1,2-dihaloalkenes featuring palladium-catalyzed coupling of haloalkynes and [alpha],[beta]-unsaturated carbonyls

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Date: May 20, 2011
From: Journal of Organic Chemistry(Vol. 76, Issue 10)
Publisher: American Chemical Society
Document Type: Report
Length: 41 words

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Abstract :

A highly regio- and stereoselective method for the synthesis of cis-1,2-dihaloalkenes through Pd-catalyzed coupling of haloalkynes and [alpha],[beta]-unsaturated carbonyls is described. The proposed method could also be applied to synthesize the functionalized conjugated enyne via the mono-Sonogashira coupling reaction of cis-1-chloro-2-iodoalkene.

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Gale Document Number: GALE|A259260302