Direct-Acting Oral Anticoagulants and Warfarin-Associated Intracerebral Hemorrhage Protocol Reduces Timing of Door to Correction Interventions

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From: Journal of Neuroscience Nursing(Vol. 51, Issue 2)
Publisher: Lippincott Williams & Wilkins, WK Health
Document Type: Report
Length: 3,599 words
Lexile Measure: 1530L

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Abstract :

Background: Intracerebral hemorrhage (ICH) is a life-threatening complication of oral anticoagulant therapy that sometimes results in hematoma expansion after onset. Our facility did not have a standardized process for treating oral anticoagulant-associated ICH; this resulted in lag times from order to reversal agent administration. Purpose: The aim of this study was to examine the impact of a rapid anticoagulant reversal protocol, combined with warfarin and direct-acting oral anticoagulant therapy, in decreasing door to first intervention times. Methods: This study used a retrospective quality assessment research approach in examining an oral anticoagulant reversal protocol to compare the control and intervention groups. Phytonadione was the first intervention treatment for most study participants diagnosed with warfarin-associated ICH with an international normalized ratio greater than 1.4. Factor IX was the first intervention treatment for all but one study participant with DOAC-associated ICH. Results: Findings were statistically significant (P Keywords: direct-acting oral anticoagulants (DOAC), international normalized ratio (INR), intracerebral hemorrhage (ICH), oral anticoagulant (OAC), oral anticoagulant-associated ICH, warfarin

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Gale Document Number: GALE|A581175527