Simultaneous orthogonal dual-click approach to tough, in-situ-forming hydrogels for cell encapsulation

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From: Journal of the American Chemical Society(Vol. 137, Issue 4)
Publisher: American Chemical Society
Document Type: Report
Length: 68 words

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Abstract :

The article describes the simultaneous application of nucleophilic thiol-yne and inverse electron-demand Diels-Alder additions to independently create two interpenetrating networks in a simple one-step procedure. The hydrogel networks exhibit compressive stresses of 14-15 MPa at 98% compression without fracture or hysteresis upon repeated load. The hydrogel networks can be spatially and temporally postfunctionalized through radical thiylation and/or inverse electron-demand Diels-Alder addition to residual functional groups within the network.

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Gale Document Number: GALE|A405190477