Interplay between renal endothelin and purinergic signaling systems

Citation metadata

Date: Sept. 2017
Publisher: American Physiological Society
Document Type: Author abstract; Report
Length: 128 words

Document controls

Main content

Abstract :

Alterations in extracellular fluid volume regulation and sodium balance may result in the development and maintenance of salt-dependent hypertension, a major risk factor for cardiovascular disease. Numerous pathways contribute to the regulation of sodium excretion and blood pressure, including endothelin and purinergic signaling. Increasing evidence suggests a link between purinergic receptor activation and endothelin production within the renal collecting duct as a means of promoting natriuresis. A better understanding of the relationship between these two systems, especially in regard to sodium homeostasis, will fill a significant knowledge gap and may provide novel antihypertensive treatment options. Therefore, this review focuses on the cross talk between endothelin and purinergic signaling as it relates to the renal regulation of sodium and blood pressure homeostasis. Sodium; blood pressure; natriuresis; kidney doi: 10.1152/ajprenal.00639.2016.

Source Citation

Source Citation   

Gale Document Number: GALE|A509728907