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    Academic Journals

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• Integrated transcriptomic analysis of human tuberculosis granulomas and a biomimetic model identifies therapeutic targets.

  Authors:Michaela T. Reichmann, Liku B. Tezera, Andres F. Vallejo, Milica Vukmirovic, Rui Xiao, James Reynolds, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 202110,394 words Report 1430LTuberculosis (TB) is a persistent global pandemic, and standard treatment for it has not changed for 30 years. Mycobacterium tuberculosis (Mtb) has undergone prolonged coevolution with humans, and patients can control...

• Circadian regulation of cardiac metabolism.

  Authors:Lilei Zhang and Mukesh K. JainFrom:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20218,010 words Article 1340LCircadian rhythm evolved to allow organisms to coordinate intrinsic physiological functions in anticipation of recurring environmental changes. The importance of this coordination is exemplified by the tight temporal...

• Assuring long-term safety of highly effective gene-modulating therapeutics for rare diseases.

  Authors:Thomas O. Crawford and Charlotte J. SumnerFrom:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20212,237 words Article 1650LA recent demonstration by Van Alstyne and colleagues (1) of long-term toxicity following short-term successful treatment of an animal model of spinal muscular atrophy (SMA) by gene transfer-mediated overexpression of...

• Canonical features of human antibodies recognizing the influenza hemagglutinin trimer interface.

  Authors:Seth J. Zost, Jinhui Dong, Iuliia M. Gilchuk, Pavlo Gilchuk, Natalie J. Thornburg, Sandhya Bangaru, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20217,894 words Report 1540LBroadly reactive antibodies targeting the influenza A virus hemagglutinin (HA) head domain are thought to be rare and to require extensive somatic mutations or unusual structural features to achieve breadth against...

• Cytomegalovirus mediates expansion of IL-15-responsive innate-memory cells with SIV killing function.

  Authors:Gema Mendez-Lagares, Ning Chin, W.L. William Chang, Jaewon Lee, Miriam Rosas- Umbert, Hung T. Kieu, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 202110,406 words Report 1380LInterindividual immune variability is driven predominantly by environmental factors, including exposure to chronic infectious agents such as cytomegalovirus (CMV). We investigated the effects of rhesus CMV (RhCMV) on...

• Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy.

  Authors:Udo F.H. Engelke, Rianne E. van Outersterp, Jona Merx, Fred A.M.G. van Geenen, Arno van Rooij, Giel Berden, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 202110,342 words Report 1510LBackground. Pyridoxine-dependent epilepsy (PDE-ALDH7A1) is an inborn error of lysine catabolism that presents with refractory epilepsy in newborns. Biallelic ALDH7A1 variants lead to deficiency of a-aminoadipic...

• The lung microbiome: progress and promise.

  Authors:Samantha A. Whiteside, John E. McGinniss, and Ronald G. CollmanFrom:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20218,985 words Report 1380LThe healthy lung was long thought of as sterile, but recent advances using molecular sequencing approaches have detected bacteria at low levels. Healthy lung bacteria largely reflect communities present in the upper...

• Tuberculosis lymph node granulomas: using transcriptomics to discover immunopathology paradigms and guide host-directed therapy.

  Authors:James J. Phelan, Seonadh O'Leary, and Joseph KeaneFrom:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20211,749 words Article 1470LImmunometabolism is a burgeoning field of investigation in tuberculosis host defense, susceptibility, and pathophysiology. Unbiased approaches to studying tuberculosis have, as expected, confirmed that pathways of...

• Doxycycline host-directed therapy in human pulmonary tuberculosis.

  Authors:Qing Hao Miow, Andres F. Vallejo, Yu Wang, Jia Mei Hong, Chen Bai, Felicia S.W. Teo, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20219,444 words Report 1410LBACKGROUND. Matrix metalloproteinases (MMPs) are key regulators of tissue destruction in tuberculosis (TB) and may be targets for host-directed therapy. We conducted a phase II double-blind, randomized, controlled trial...

• Decreased vaccine protection of egg-based influenza vaccine in the elderly and nonhemagglutinin-focused immunity.

  Authors:Karen J. Gonzalez and Eva M. StrauchFrom:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20211,924 words Article 1650LSevere influenza illness or death is a serious concern among the elderly population despite vaccination. To investigate how the adaptive immune response after vaccination varies with the patient's age, Jung et al., in a...

• Serine hydroxymethyltransferase 2 expression promotes tumorigenesis in rhabdomyosarcoma with 12q13-q14 amplification.

  Authors:Thanh H. Nguyen, Prasantha L. Vemu, Gregory E. Hoy, Salah Boudjadi, Bishwanath Chatterjee, Jack F. Shern, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20219,955 words Report 1440LThe 12q13-q14 chromosomal region is recurrently amplified in 25% of fusion- positive (FP) rhabdomyosarcoma (RMS) cases and is associated with a poor prognosis. To identify amplified oncogenes in FP RMS, we compared the...

• Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype.

  Authors:Laura Lecce, Yang Xu, Bhargavi V'Gangula, Nirupama Chandel, Venu Pothula, Axelle Caudrillier, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 202112,424 words Report 1440LEndothelial-mesenchymal transition (EndMT) is associated with various cardiovascular diseases and in particular with atherosclerosis and plaque instability. However, the molecular pathways that govern EndMT are poorly...

• Dysregulation of mannose-6-phosphate-dependent cholesterol homeostasis in acinar cells mediates pancreatitis.

  Authors:Olga A. Mareninova, Eszter T. Vegh, Natalia Shalbueva, Carli J.M. Wightman, Dustin L. Dillon, Sudarshan Malla, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 202112,371 words Report 1390LDisordered lysosomal/autophagy pathways initiate and drive pancreatitis, but the underlying mechanisms and links to disease pathology are poorly understood. Here, we show that the mannose-6-phosphate (M6P) pathway of...

• Innovative treatment as a precursor to clinical research.

  Authors:David Wendler, Seher Anjum, and Peter WilliamsonFrom:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20212,456 words Article 1380LReliance on randomized controlled trials (RCTs) as the gold standard for assessing therapeutics began in 1948, with the widely cited trial of streptomycin for pulmonary tuberculosis (1). Less widely recognized is the...

• Extracellular matrix protein laminin [beta]1 regulates pain sensitivity and anxiodepression-like behaviors in mice.

  Authors:Zhen-Zhen Li, Wen-Juan Han, Zhi-Chuan Sun, Yun Chen, Jun-Yi Sun, Guo- Hong Cai, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 202112,453 words Report 1420LPatients with neuropathic pain often experience comorbid psychiatric disorders. Cellular plasticity in the anterior cingulate cortex (ACC) is assumed to be a critical interface for pain perception and emotion. However,...

• Interconnections between circadian clocks and metabolism.

  Authors:Dongyin Guan and Mitchell A. LazarFrom:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 202110,801 words Article 1320LCircadian rhythms evolved through adaptation to daily light/dark changes in the environment; they are believed to be regulated by the core circadian clock interlocking feedback loop. Recent studies indicate that each...

• Association of rare predicted loss-of-function variants of influenza-related type I IFN genes with critical COVID-19 pneumonia.

  Authors:Qian Zhang, Aurelie Cobat, Paul Bastard, Luigi D. Notarangelo, Helen C. Su, Laurent Abel, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20211,582 words Letter to the editor 1600LTo the Editor: Povysil et al. report that "rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19" (1). We disagree with the authors' interpretation of our data (2) and their...

• The clear cell sarcoma functional genomic landscape.

  Authors:Emanuele Panza, Benjamin B. Ozenberger, Krystal M. Straessler, Jared J. Barrott, Li Li, Yanliang Wang, et al.From:Journal of Clinical Investigation (Vol. 131, Issue 15) Peer-Reviewed

  Aug. 1, 20219,316 words Report 1470LClear cell sarcoma (CCS) is a deadly malignancy affecting adolescents and young adults. It is characterized by reciprocal translocations resulting in expression of the chimeric EWSR1-ATF1 or EWSR1-CREB1 fusion proteins,...