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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedSkeletal muscle preeminently determines whole-body glycemla. However, the molecular basis and inheritable influence that drive the progression of insulin resistance to type 2 diabetes remain debated. In this issue of the...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedInflammatory disorders of the skin are frequently associated with inflammatory bowel diseases (IBDs). To explore mechanisms by which these organs communicate, we performed single-cell RNA-Seq analysis on fibroblasts from...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedCortical spreading depression (CSD), a wave of depolarization followed by depression of cortical activity, is a pathophysiological process implicated in migraine with aura and various other brain pathologies, such as...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedAberrant activation of telomerase in human cancer is achieved by various alterations within the TERT promoter, including cancer-specific DNA hypermethylation of the TERT hypermethylated oncological region (THOR)....
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedDirect allorecognition, the ability of host T cells to recognize intact allogeneic MHC molecules on transplanted tissues, is often assumed to be less dependent on the peptide bound to the MHC molecule than are other...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedCritical periods are developmental time windows in which functional properties of the brain are particularly susceptible to the organism's experience. It was thought that therapeutic strategies for neurodevelopmental...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedWhile direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly alloreactive [CD8.sup.+] T cells have not been defined. In this study,...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedAlthough serine metabolism plays a crucial role in the proliferation and survival of tumor cells, how it supports tumor cell migration remains poorly understood. Phosphoglycerate dehydrogenase (PHGDH) catalyzes the...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of coronavirus disease 2019 (COVID-19). Little is known about the interplay between preexisting immunity to endemic seasonal coronaviruses and the...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedSomatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndromes. U2AF1 mutations that code for the most common amino acid substitutions are always heterozygous, and the retained WT...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedIt has been estimated that in the first six months of 2021, mRNA-based vaccines against SARS-CoV-2 have saved 280,000 lives in the US alone and prevented well over a million hospitalizations. It is the scientific body of...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedFormation of NO by endothelial NOS (eNOS) is a central process in the homeostatic regulation of vascular functions including blood pressure regulation, and fluid shear stress exerted by the flowing blood is a main...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedCentral obesity with cardiometabolic syndrome (CMS) is a major global contributor to human disease, and effective therapies are needed. Here, we show that cyclic GMP-selective phosphodiesterase 9A inhibition (PDE9-I) in...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedPeripheral nerves have the capacity for regeneration, but the rate of regeneration is so slow that many nerve injuries lead to incomplete recovery and permanent disability for patients. Macrophages play a critical role...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedInsulin resistance is present in one-quarter of the general population, predisposing these people to a wide range of diseases. Our aim was to identify cell-intrinsic determinants of insulin resistance in this population...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedTo explore how the immune system controls clearance of SARS-CoV-2, we used a single-cell, mass cytometry-based proteomics platform to profile the immune systems of 21 patients who had recovered from SARS-CoV-2 infection...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedIn this study, we demonstrate that forkhead box F1 (FOXF1), a mesenchymal transcriptional factor essential for lung development, was retained in a topographically distinct mesenchymal stromal cell population along the...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedShear stress is an important regulator of blood flow, and luminal endothelial cells (ECs) sense increases in frictional forces and respond with an appropriate release of vasoactive mediators. In this issue of the JCI,...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedSpreading depolarizations (SDs) are involved in migraine, epilepsy, stroke, traumatic brain injury, and subarachnoid hemorrhage. However, the cellular origin and specific differential mechanisms are not clear. Increased...
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From:Journal of Clinical Investigation (Vol. 131, Issue 21) Peer-ReviewedThe world lost a leader in medicine, public health, and global health on August 4, 2021 when Tadataka "Tachi" Yamada passed away at the age of 76 (Figure 1). Tachi was a scientist, an entrepreneur, an outstanding mentor,...